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Journal of Neurological Sciences (Turkish)
2008, Volume 25, Number 3, Page(s) 155-162
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Effects of Repeated Maternal Separation On Oxidative Stress In Adolescent Male and Female Rat Brains
Nazan UYSAL1, Ali Riza SISMAN2, Sevil GONENC1, Osman ACIKGOZ1, Berkant Muammer KAYATEKIN1, Giray YALAZ1
1Dokuz Eylul University, School of Medicine, Department of Physiology, Balcova, Izmir, Turkey
2Dokuz Eylul University, School of Medicine, Department of Biochemistry, Balcova, Izmir, Turkey
Keywords: Maternal separation, oxidative stress, lipid peroxidation, prefrontal cortex, hippocampus, striatum.

In a previous study we demonstrated that repeated maternal separation impaired spatial memory performance in both male and female adolescent rats. The mechanisms of these cognitive alterations are unknown. In the present study, we examined the effects of repeated maternal separation on oxidative stress in the hippocampus, prefrontal cortex and striatum regions of the brain of the adolescent male and female rats. The results showed that repeated maternal separation increased antioxidant enzyme activities and lipid peroxidation in adolescent male rat brains; however, maternal separation did not effects antioxidant enzyme activities and lipid peroxidation in adolescent female rat brains. These results suggest that oxidative stress caused damage in repeated maternal separated adolescent male rat brains, also a strong role of gender in the response of adolescent subjects to maternal separation.

How to cite this article:
N. UYSAL, A. R. SISMAN, S. GONENC, O. ACIKGOZ, B. M. KAYATEKIN, G. YALAZ: Effects of Repeated Maternal Separation On Oxidative Stress In Adolescent Male and Female Rat Brains. J Neurol Sci [Turk] 2008;25:155-162

How to cite this URL & PDF:
N. UYSAL, A. R. SISMAN, S. GONENC, O. ACIKGOZ, B. M. KAYATEKIN, G. YALAZ: Effects of Repeated Maternal Separation On Oxidative Stress In Adolescent Male and Female Rat Brains. J Neurol Sci [Turk] 2008 [cited 2008 September 25];25:155-162. Available from: http://jns.dergisi.org/text.php3?id=231 PDF: http://jns.dergisi.org/pdf/pdf_JNS_231.pdf

E-mail of the corresponding author: nazan.uysal@deu.edu.tr


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